Overview of the muscle cytoskeleton (2023)

Henderson, C. A., Gomez, C. G., Novak, S. M., Mi-Mi, L. (2017). Overview of the muscle cytoskeleton. Comprehensive Physiology, 7(3), 891-944. https://doi.org/10.1002/cphy.c160033

Henderson, Christine A. ; Gomez, Christopher G. ; Novak, Stefanie M. et al. / Overview of the muscle cytoskeleton. In: Comprehensive Physiology. 2017 ; Vol. 7, No. 3. pp. 891-944.

@article{8860f56ee1ee490ba42d065c158d1052,

title = "Overview of the muscle cytoskeleton",

abstract = "Cardiac and skeletal striated muscles are intricately designed machines responsible for muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the complex cytoskeletal networks are critical for contractile activity. The sarcomere is comprised of precisely organized individual filament systems that include thin (actin), thick (myosin), titin, and nebulin. Connecting the sarcomere to other organelles (e.g., mitochondria and nucleus) and serving as the scaffold to maintain cellular integrity are the intermediate filaments. The costamere, on the other hand, tethers the sarcomere to the cell membrane. Unique structures like the intercalated disc in cardiac muscle and the myotendinous junction in skeletal muscle help synchronize and transmit force. Intense investigation has been done on many of the proteins that make up these cytoskeletal assemblies. Yet the details of their function and how they interconnect have just started to be elucidated. A vast number of human myopathies are contributed to mutations in muscle proteins; thus understanding their basic function provides a mechanistic understanding of muscle disorders. In this review, we highlight the components of striated muscle with respect to their interactions, signaling pathways, functions, and connections to disease.",

author = "Henderson, {Christine A.} and Gomez, {Christopher G.} and Novak, {Stefanie M.} and Lei Mi-Mi and Gregorio, {Carol C.}",

note = "Funding Information: This work was funded by National Institutes of Health R01HL108625 and R01HL123078 (C. C. Gregorio), the University of Arizona Sarver Heart Center Finley and Florence Brown Endowed ResearchAward (C. A. Henderson), the University of Arizona Undergraduate Biology Research Program (C. G. Gregorio), National Institutes of Health Predoctoral Fellowship 1F31HL117520 (S. M. Novak), and an American Heart Association Western State Affiliates Postdoctoral Fellowship 16POST31350016 (L. Mi-Mi). Publisher Copyright: {\textcopyright} 2017 American Physiological Society.",

year = "2017",

month = jul,

day = "1",

doi = "10.1002/cphy.c160033",

language = "English",

volume = "7",

pages = "891--944",

journal = "Comprehensive Physiology",

issn = "2040-4603",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

Henderson, CA, Gomez, CG, Novak, SM, Mi-Mi, L 2017, 'Overview of the muscle cytoskeleton', Comprehensive Physiology, vol. 7, no. 3, pp. 891-944. https://doi.org/10.1002/cphy.c160033

Overview of the muscle cytoskeleton. / Henderson, Christine A.; Gomez, Christopher G.; Novak, Stefanie M. et al.
In: Comprehensive Physiology, Vol. 7, No. 3, 01.07.2017, p. 891-944.

Research output: Contribution to journal › Article › peer-review

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T1 - Overview of the muscle cytoskeleton

AU - Henderson, Christine A.

AU - Gomez, Christopher G.

AU - Novak, Stefanie M.

AU - Mi-Mi, Lei

AU - Gregorio, Carol C.

N1 - Funding Information:This work was funded by National Institutes of Health R01HL108625 and R01HL123078 (C. C. Gregorio), the University of Arizona Sarver Heart Center Finley and Florence Brown Endowed ResearchAward (C. A. Henderson), the University of Arizona Undergraduate Biology Research Program (C. G. Gregorio), National Institutes of Health Predoctoral Fellowship 1F31HL117520 (S. M. Novak), and an American Heart Association Western State Affiliates Postdoctoral Fellowship 16POST31350016 (L. Mi-Mi).Publisher Copyright:© 2017 American Physiological Society.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Cardiac and skeletal striated muscles are intricately designed machines responsible for muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the complex cytoskeletal networks are critical for contractile activity. The sarcomere is comprised of precisely organized individual filament systems that include thin (actin), thick (myosin), titin, and nebulin. Connecting the sarcomere to other organelles (e.g., mitochondria and nucleus) and serving as the scaffold to maintain cellular integrity are the intermediate filaments. The costamere, on the other hand, tethers the sarcomere to the cell membrane. Unique structures like the intercalated disc in cardiac muscle and the myotendinous junction in skeletal muscle help synchronize and transmit force. Intense investigation has been done on many of the proteins that make up these cytoskeletal assemblies. Yet the details of their function and how they interconnect have just started to be elucidated. A vast number of human myopathies are contributed to mutations in muscle proteins; thus understanding their basic function provides a mechanistic understanding of muscle disorders. In this review, we highlight the components of striated muscle with respect to their interactions, signaling pathways, functions, and connections to disease.

AB - Cardiac and skeletal striated muscles are intricately designed machines responsible for muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the complex cytoskeletal networks are critical for contractile activity. The sarcomere is comprised of precisely organized individual filament systems that include thin (actin), thick (myosin), titin, and nebulin. Connecting the sarcomere to other organelles (e.g., mitochondria and nucleus) and serving as the scaffold to maintain cellular integrity are the intermediate filaments. The costamere, on the other hand, tethers the sarcomere to the cell membrane. Unique structures like the intercalated disc in cardiac muscle and the myotendinous junction in skeletal muscle help synchronize and transmit force. Intense investigation has been done on many of the proteins that make up these cytoskeletal assemblies. Yet the details of their function and how they interconnect have just started to be elucidated. A vast number of human myopathies are contributed to mutations in muscle proteins; thus understanding their basic function provides a mechanistic understanding of muscle disorders. In this review, we highlight the components of striated muscle with respect to their interactions, signaling pathways, functions, and connections to disease.

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SN - 2040-4603

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JF - Comprehensive Physiology

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Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC. Overview of the muscle cytoskeleton. Comprehensive Physiology. 2017 Jul 1;7(3):891-944. doi: 10.1002/cphy.c160033